The discovery and quantification of adverse drug reactions has long relied on the careful
analysis of spontaneously reported cases. Causality assessment (imputation) was a …

Inhaled corticosteroids (ICSs) are indicated for the prevention of exacerbations in COPD;
however, a significant proportion of patients at low risk of exacerbations are treated with …

Background Neutrophil extracellular traps (NETs) have been observed in the airway in
patients with chronic obstructive pulmonary disease (COPD), but their clinical and …

Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden
and is currently the 4th largest cause of death in the world. Importantly, much of the disease …

Purpose Lack of control for time‐varying exposures can lead to substantial bias in estimates
of treatment effects. The aim of this study is to provide an overview and guidance on some of …

Time is a crucial parameter in the assessment of comorbidities in population-based studies,
as it permits to identify more complex disease patterns apart from the pairwise disease …

Initial use of inhaled corticosteroid therapy is common in patients with Global Initiative for
Chronic Obstructive Lung Disease (GOLD) A or B chronic obstructive pulmonary disease …

Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) often
coexist. The mechanistic links between these two diseases are complex, multifactorial, and …

At the time of their marketing authorization, the effects of drugs and especially their efficacy
have been mostly studied in randomized controlled clinical trials (RCT), comparing them to …

The skeletal effects of inhaled glucocorticoids are poorly understood. Children with asthma
treated with inhaled glucocorticoids have lower growth velocity, bone density, and adult …