Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …

Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Highlights•Curcumin reversed LPS-induced decrease in BV2 cell viability and
morphological changes.•Curcumin promoted microglial polarization from the M1 to the M2 …

Microglia play critical roles in brain development, homeostasis, and neurological disorders.
Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to …

Innate immune responses, particularly activation of macrophages and microglia, are
increasingly implicated in CNS disorders. It is now appreciated that the heterogeneity of …

Activation of the inflammasome is implicated in the pathogenesis of an increasing number of
inflammatory diseases, including Alzheimer's disease (AD). Research reporting …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Alzheimer's disease (AD) is the most common form of dementia and the 6th leading cause of
death in the US. The neuropathological hallmarks of the disease are extracellular amyloid-β …

Alzheimer's disease (AD) is a neurodegenerative disease, in which the primary etiology
remains unknown. AD presents amyloid beta (Aβ) protein aggregation and neurofibrillary …

Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …