Discoveries in cancer research are rarely so exceptional that they both cause immediate
changes in the treatment of patients and dramatically advance our understanding of the …

A CUTE PROMYELOCYTIC leukemia (APL) has aroused interest well beyond the
hematologic field during the last 4 to 5 years. Two features, both of which are unique to APL …

Acute promyelocytic leukemia (APL) is typified by the t (15; 17), generating the PML-RARα
fusion and predicting a beneficial response to retinoids. However, a sizeable minority of APL …

Acute promyelocytic leukemia (APL) is characterized by a number of features that underpin
the need for rapid and accurate diagnosis and demand a highly specific treatment approach …

Abstract The Second International Symposium on Acute Promyelocytic Leukemia (APL) was
held in Rome in 12–14 November 1997. Clinical and basic investigators had the opportunity …

Early infancy (< 1 year of age), massive tumor cell burden, and extremely poor prognosis are
characteristic features of a particular subset of childhood acute leukemias (AL). In these …

Acute myeloid leukemia (AML) is characterized by a differentiation block leading to
accumulation of immature cells. Chromosomal translocations in AML affect transcription …

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal
fusion genes: one thought to be involved in the transformation process, the other the …

Neutrophil elastase (NE) is a neutrophil‑derived serine proteinase with specificity for a broad
range of substrates. NE has been reported to be associated with the pathogenesis of several …

Retinoic acids (RAs) exert a broad range of physiologic actions during embryonic
development and adult life. Two families of RA receptors, retinoic acid receptor (RAR) and …