Immunomodulatory effect of ginsenoside Rb2 against cyclophosphamide-induced immunosuppression in mice

S Zheng, H Zheng, R Zhang, X Piao, J Hu… - Frontiers in …, 2022 - frontiersin.org
Ginsenoside Rb2 (Rb2), a fundamental saponin produced and isolated from ginseng
(Panax ginseng CA Meyer), has a wide range of biological actions. The objective of this …

Associations between metabolic syndrome and four heavy metals: a systematic review and meta-analysis

P Xu, A Liu, F Li, AA Tinkov, L Liu, JC Zhou - Environmental Pollution, 2021 - Elsevier
Four most concerned heavy metal pollutants, arsenic, cadmium, lead, and mercury may
share common mechanisms to induce metabolic syndrome (MetS). However, recent studies …

Curcumin protects the testis against cadmium-induced histopathological damages and oxidative stress in mice

HR Momeni, N Eskandari - Human & experimental …, 2020 - journals.sagepub.com
Background: Cadmium is an environmental pollutant which can induce the overproduction
of free radicals while suppressing the antioxidant defense system. Curcumin is considered a …

The effect of repeated cadmium oral exposure on the level of sex hormones, estrous cyclicity, and endometrium morphometry in female rats

M Nasiadek, M Danilewicz, K Sitarek… - … Science and Pollution …, 2018 - Springer
Cadmium (Cd) is regarded as a potential endocrine disruptor. However, the exact
mechanism by which this metal may interfere with the reproductive system has not yet been …

Autophagy as a molecular target of quercetin underlying its protective effects in human diseases

M Ashrafizadeh, Z Ahmadi, T Farkhondeh… - … of Physiology and …, 2022 - Taylor & Francis
Autophagy, known as a “self-eating” process, is associated with degradation of aged or
damaged components and organelles. Generally, autophagy is a survival mechanism that …

Resveratrol targeting the Wnt signaling pathway: a focus on therapeutic activities

M Ashrafizadeh, Z Ahmadi… - Journal of cellular …, 2020 - Wiley Online Library
Wingless‐type MMTV integration site (Wnt) signaling pathway is considered as an important
pathway regulating a variety of biological processes such as tissue formation and …

Modulatory effects of statins on the autophagy: A therapeutic perspective

M Ashrafizadeh, Z Ahmadi… - Journal of Cellular …, 2020 - Wiley Online Library
Autophagy is considered as an important mechanism for maintaining homeostasis and
responsible for the degradation of superfluous or potentially toxic components and …

Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

T Farkhondeh, AM Pourbagher-Shahri… - Neural regeneration …, 2020 - journals.lww.com
The over-activated microglial cells induce neuroinflammation which has the main role in
neurological disorders. The over-activated microglia can disturb neuronal function by …

Arsenite-induced transgenerational glycometabolism is associated with up-regulation of H3K4me2 via inhibiting spr-5 in Caenorhabditis elegans

C Gu, Y Wen, L Wu, Y Wang, Q Wu, D Wang, Y Wang… - Toxicology Letters, 2020 - Elsevier
Arsenic (As) is a toxic element that is highly abundant in the environment. However, there
has not been sufficient research into the mechanisms of arsenic-induced transgenerational …

Puerarin attenuates cadmium-induced hepatic lipid metabolism disorder by inhibiting oxidative stress and inflammation in mice

XM Wan, J Chen, M Wang, C Zheng, XL Zhou - Journal of inorganic …, 2021 - Elsevier
Cadmium (Cd) is a common environmental pollutant with known toxic effects on the liver.
Puerarin (PU), a natural flavonoid, has been shown to exert protective effect in numerous …