[HTML][HTML] Selection and Amplification of Fungicide Resistance in Aspergillus fumigatus in Relation to DMI Fungicide Use in Agronomic Settings: Hotspots versus …

KJ Doughty, H Sierotzki, M Semar, A Goertz - Microorganisms, 2021 - mdpi.com
Aspergillus fumigatus is a ubiquitous saprophytic fungus. Inhalation of A. fumigatus spores
can lead to Invasive Aspergillosis (IA) in people with weakened immune systems. The use of …

[HTML][HTML] The transcription factor FgAtrR regulates asexual and sexual development, virulence, and DON production and contributes to intrinsic resistance to azole …

Y Zhao, H Sun, J Li, C Ju, J Huang - Biology, 2022 - mdpi.com
Simple Summary Fusarium graminearum is a devastating plant pathogen that can cause
wheat head blight. Azole fungicides are commonly used chemicals for control of this …

[HTML][HTML] Allergic Diseases Caused by Aspergillus Species in Patients with Cystic Fibrosis

AK Curran, DL Hava - Antibiotics, 2021 - mdpi.com
Aspergillus spp. are spore forming molds; a subset of which are clinically relevant to humans
and can cause significant morbidity and mortality. A. fumigatus causes chronic infection in …

[HTML][HTML] Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?

I Gonzalez-Jimenez, J Lucio, A Roldan, L Alcazar-Fuoli… - Molecules, 2021 - mdpi.com
Invasive aspergillosis, mainly caused by Aspergillus fumigatus, can lead to severe clinical
outcomes in immunocompromised individuals. Antifungal treatment, based on the use of …

[HTML][HTML] Commercial Methods for Antifungal Susceptibility Testing of Saprophytic Molds: Can They Be Used to Detect Resistance?

P Paranos, A Espinel-Ingroff, J Meletiadis - Journal of Fungi, 2024 - mdpi.com
Commercial tests are often employed in clinical microbiology laboratories for antifungal
susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values …

Insights into the role of sphingolipids in antifungal drug resistance

S Kalra, S Tanwar, VK Bari - Fungal Biology Reviews, 2024 - Elsevier
Sphingolipids are major constituents of the plasma membrane that can act as structural and
signalling molecules in diverse organisms such as animals, plants, and fungi. The …

[HTML][HTML] CYP51 Mutations in the Fusarium solani Species Complex: First Clue to Understand the Low Susceptibility to Azoles of the Genus Fusarium

P Vermeulen, A Gruez, AL Babin, JP Frippiat… - Journal of Fungi, 2022 - mdpi.com
Members of Fusarium solani species complex (FSSC) are cosmopolitan filamentous fungi
responsible for invasive fungal infections in immunocompromised patients. Despite the …

Analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets?

EF Warner, N Bohálová, V Brázda… - Microbial …, 2021 - microbiologyresearch.org
Fungal infections cause> 1 million deaths annually and the emergence of antifungal
resistance has prompted the exploration for novel antifungal targets. Quadruplexes are four …

Azole resistance in Aspergillus species: promising therapeutic options

S Pasula, PH Chandrasekar - Expert Opinion on Pharmacotherapy, 2021 - Taylor & Francis
Introduction Azoles are the first-line antifungal agents used for the treatment of Aspergillus
infection. There is an increasing concern for azole resistance all over the world mainly from …

[PDF][PDF] Is an azole-resistant Aspergillus hotspot emerging in South-East Asia

N van Rhijn, DW Denning - Environ. Microbiol, 2021 - gaffi.org
Azole resistance in Aspergillus is much prevalent than it used to be and further emphasized
by a paper in this issue from Vietnam (Duong et al., nd). The implications for human health …