Anti‐inflammatory hydrogel dressings and skin wound healing

C Huang, L Dong, B Zhao, Y Lu… - Clinical and …, 2022 - Wiley Online Library
Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐
inflammatory function of hydrogel dressings has been significantly improved, addressing …

Immunomodulatory biomaterials for tissue repair

R Whitaker, B Hernaez-Estrada… - Chemical …, 2021 - ACS Publications
All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Mesenchymal stromal cell apoptosis is required for their therapeutic function

SHM Pang, J D'Rozario, S Mendonca, T Bhuvan… - Nature …, 2021 - nature.com
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

[HTML][HTML] Macrophages as a therapeutic target to promote diabetic wound healing

M Sharifiaghdam, E Shaabani, R Faridi-Majidi… - Molecular Therapy, 2022 - cell.com
It is well‏‏ established that macrophages are key regulators of wound healing, displaying
impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or" …

Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Mesenchymal stromal cells: clinical challenges and therapeutic opportunities

J Galipeau, L Sensébé - Cell stem cell, 2018 - cell.com
Mesenchymal stromal cells (MSCs) have been the subject of clinical trials for more than a
generation, and the outcomes of advanced clinical trials have fallen short of expectations …