Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Core clinical pharmacology principles must be considered when designing and executing
neonatal clinical trials. In this review, the authors discuss important aspects of drug dose …

Background Children with medical complexity (CMC) are a priority pediatric population, with
high resource use and associated costs. Genome-wide sequencing is increasingly …

Introduction Despite many research efforts, current data on the safety of medicines during
breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most …

Introduction Information on the impact of medicines on breastfeeding and the breastfed
infant remains scarce. The aims of this review were to identify databases and cohorts …

Introduction Assessment of drug-related adverse events is essential to fully understand the
benefit-risk balance of any drug exposure, weighing efficacy versus safety. This is needed …

A paper on population pharmacokinetics (PK), pharmacogenetics (PGx) and
pharmacodynamics (PD) of fentanyl in preterm neonates undergoing a skin-breaking …

The two primary classes of opioid substances are morphine and its synthetic derivative,
heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any …

Precision Medicine is an approach to disease treatment and prevention taking into account
individual genetic, environmental, therapeutic and lifestyle variability for each person. This …

Newborn screening (NBS) is based on pre-symptomatic testing for genetic diagnoses to
enhance outcomes through diet or specific therapeutic interventions. Some even argue that …