Developmental pharmacokinetics of antibiotics used in neonatal ICU: focus on preterm infants
OI Butranova, EA Ushkalova, SK Zyryanov… - Biomedicines, 2023 - mdpi.com
Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …
Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials
CHT Yeung, RHJ Verstegen, R Greenberg… - Frontiers in …, 2024 - frontiersin.org
Core clinical pharmacology principles must be considered when designing and executing
neonatal clinical trials. In this review, the authors discuss important aspects of drug dose …
neonatal clinical trials. In this review, the authors discuss important aspects of drug dose …
Pharmacogenetic profiling via genome sequencing in children with medical complexity
A Pan, S Scodellaro, T Khan, I Ushcatz, W Wu… - Pediatric …, 2023 - nature.com
Background Children with medical complexity (CMC) are a priority pediatric population, with
high resource use and associated costs. Genome-wide sequencing is increasingly …
high resource use and associated costs. Genome-wide sequencing is increasingly …
Safety of medicines during breastfeeding–from case report to modeling: a contribution from the ConcePTION project
E Cardoso, M Guidi, N Nauwelaerts… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Despite many research efforts, current data on the safety of medicines during
breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most …
breastfeeding are either fragmented or lacking, resulting in restrictive labeling of most …
Where are the data linking infant outcomes, breastfeeding and medicine exposure? A systematic scoping review
Introduction Information on the impact of medicines on breastfeeding and the breastfed
infant remains scarce. The aims of this review were to identify databases and cohorts …
infant remains scarce. The aims of this review were to identify databases and cohorts …
Drug related adverse event assessment in neonates in clinical trials and clinical care
N Yalcin, J van den Anker… - Expert review of …, 2024 - Taylor & Francis
Introduction Assessment of drug-related adverse events is essential to fully understand the
benefit-risk balance of any drug exposure, weighing efficacy versus safety. This is needed …
benefit-risk balance of any drug exposure, weighing efficacy versus safety. This is needed …
Fentanyl in neonates, a population pharmacokinetic,-genetic and-dynamic study
N Yalçın, K Allegaert - Pediatric research, 2024 - nature.com
A paper on population pharmacokinetics (PK), pharmacogenetics (PGx) and
pharmacodynamics (PD) of fentanyl in preterm neonates undergoing a skin-breaking …
pharmacodynamics (PD) of fentanyl in preterm neonates undergoing a skin-breaking …
Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for …
E Giovannini, MP Bonasoni, JP Pascali, C Bini… - Children, 2024 - mdpi.com
The two primary classes of opioid substances are morphine and its synthetic derivative,
heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any …
heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any …
Advancing Precision Medicine in Paediatrics: Past, present and future
Precision Medicine is an approach to disease treatment and prevention taking into account
individual genetic, environmental, therapeutic and lifestyle variability for each person. This …
individual genetic, environmental, therapeutic and lifestyle variability for each person. This …
Fetal pharmacogenetic screening to improve neonatal pharmacotherapy: From feasibility to personalized practice
N Yalcin, K Allegaert - Molecular genetics and metabolism, 2022 - Elsevier
Newborn screening (NBS) is based on pre-symptomatic testing for genetic diagnoses to
enhance outcomes through diet or specific therapeutic interventions. Some even argue that …
enhance outcomes through diet or specific therapeutic interventions. Some even argue that …