Trypanosomes are a group of protozoan eukaryotes, many of which are major parasites of
humans and livestock. The genomes of trypanosomes and their modes of gene expression …

Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular
processes, including transcription, replication, and repair. Vast arrays of modifications have …

Benznidazole (BZ) is the most commonly used drug for the treatment of Chagas disease.
Although BZ is known to induce the formation of free radicals and electrophilic metabolites …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes
and undergo several post-translational modifications, which are important for the control of …

Histone post-translational modification, mediated by histone acetyltransferases and
deacetylases, is one of the most studied factors affecting gene expression. Recent data …

Parasitic protozoa comprise several species that are causative agents of important diseases.
These diseases are distributed throughout the world and include leishmaniasis, Chagas …

Trypanosomatids present unusual organelles, such as the kinetoplast that contains the
mitochondrial DNA arranged in catenated circles. The nucleus of these protozoa presents …