Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …

Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

RNA interference (RNAi)-based technologies offer an attractive strategy for the sequence-
specific silencing of disease-causing genes. The application of small interfering (si) RNAs as …

This review focuses on the monophyletic group of animal RNA viruses united in the order
Nidovirales. The order includes the distantly related coronaviruses, toroviruses, and …

The HIV-1 accessory protein Vpu counteracts a host factor that restricts virion release from
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …

Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …