[HTML][HTML] Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - … and Targeted Therapy, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Microglia play an active role in obesity-associated cognitive decline

EC Cope, EA LaMarca, PK Monari… - Journal of …, 2018 - Soc Neuroscience
Obesity affects> 600 million people worldwide, a staggering number that appears to be on
the rise. One of the lesser known consequences of obesity is its deleterious effects on …

[HTML][HTML] Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

[HTML][HTML] Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders

Q Li, X Shao, X Dai, Q Guo, B Yuan, Y Liu… - NPG Asia …, 2022 - nature.com
The central nervous system (CNS) controls the acquisition and processing of peripheral
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …

Is graphene shortening the path toward spinal cord regeneration?

AF Girão, MC Serrano, A Completo, PAAP Marques - ACS nano, 2022 - ACS Publications
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …

Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury

Z Nazemi, MS Nourbakhsh, S Kiani, Y Heydari… - Journal of controlled …, 2020 - Elsevier
Spinal cord injury (SCI) induces pathological and inflammatory responses that create an
inhibitory environment at the site of trauma, resulting in axonal degeneration and functional …

The overlooked aspect of excitotoxicity: Glutamate‐independent excitotoxicity in traumatic brain injuries

J Tehse, C Taghibiglou - European journal of neuroscience, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a leading major cause of morbidity and mortality in youth and
individuals under 45 year age. A wide variety of cellular and molecular mechanisms have …

[HTML][HTML] Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

SF Abcouwer, S Shanmugam, A Muthusamy… - Journal of …, 2021 - Springer
Background Several retinal pathologies exhibit both inflammation and breakdown of the
inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that …

Melatonin enhances autophagy and reduces apoptosis to promote locomotor recovery in spinal cord injury via the PI3K/AKT/mTOR signaling pathway

Y Li, Y Guo, Y Fan, H Tian, K Li, X Mei - Neurochemical research, 2019 - Springer
Spinal cord injury (SCI) leads to neuronal death resulting in central nervous system (CNS)
dysfunction; however, the pathogenesis is still poorly understood. Melatonin (MT), a …