Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease
T Athar, K Al Balushi, SA Khan - Molecular biology reports, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
Alzheimer's disease: key insights from two decades of clinical trial failures
CK Kim, YR Lee, L Ong, M Gold… - Journal of Alzheimer's …, 2022 - content.iospress.com
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development
over the past two decades, the objective of this review was to derive key insights from the …
over the past two decades, the objective of this review was to derive key insights from the …
Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …
public health problem due to the rising incidence and lack in effective therapies. Since …
Recent progress on tubulin inhibitors with dual targeting capabilities for cancer therapy
W Shuai, G Wang, Y Zhang, F Bu, S Zhang… - Journal of Medicinal …, 2021 - ACS Publications
Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …
and organelle trafficking, which makes the microtubule an important target for cancer …
[HTML][HTML] Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model
L Yang, C Wu, E Parker, Y Li, Y Dong, L Tucker… - Theranostics, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing
neuronal degeneration and cognitive deficits that significantly impair independence and …
neuronal degeneration and cognitive deficits that significantly impair independence and …
Single-target versus multi-target drugs versus combinations of drugs with multiple targets: preclinical and clinical evidence for the treatment or prevention of epilepsy
W Löscher - Frontiers in pharmacology, 2021 - frontiersin.org
Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …
Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis
ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations
RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …
Computer especially AI-assisted drug virtual screening and design in traditional Chinese medicine
Y Lin, Y Zhang, D Wang, B Yang, YQ Shen - Phytomedicine, 2022 - Elsevier
Abstract Background Traditional Chinese medicine (TCM), as a significant part of the global
pharmaceutical science, the abundant molecular compounds it contains is a valuable …
pharmaceutical science, the abundant molecular compounds it contains is a valuable …