Background White matter hyperintensities of presumed vascular origin (WMH) are one of the
imaging features of cerebral small vessel disease. Controversies persist about the effects of …

Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear
pathophysiology for AD has not been confirmed, and effective treatments are still not …

Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …

Background Cerebral small vessel disease (CSVD) comprises a variety of disorders
affecting small arteries and microvessels of the brain, manifesting as white matter …

White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel
disease. WMHs are also frequently observed in patients with familial and sporadic …

Oxidative stress is an early occurrence in the development of Alzheimer's disease (AD) and
one of its proposed etiologic hypotheses. There is sufficient experimental evidence …

White matter hyperintensities (WMHs) are associated with poorer brain health, but their
pathophysiological substrates remain elusive. To better understand the mechanistic …

Elevated expression of human hyperphosphorylated tau is associated with neuronal loss
and white matter (WM) pathology in Alzheimer's disease (AD) and related …

Background Two of the main causes for dementia are Alzheimer's disease (AD) and
vascular pathology, with most patients showing mixed pathology. Plasma biomarkers for …

Aims/hypothesis Type 2 diabetes is an independent risk factor for cognitive decline. Insulin
resistance occurring during midlife may increase the risk of cognitive decline later in life. We …