Introduction Aggressive variants of papillary thyroid cancer (PTC) have been described with
increasing frequency. These variants include diffuse sclerosing variant, tall cell variant …

Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular
pathology of thyroid tumours originating from follicular cells has greatly advanced in the past …

Ganglioglioma is a rare CNS tumor with a benign biological behavior. Recently, the BRAF
V600E mutation was identified in approximately 20% of gangliogliomas. Here, we analyzed …

The significance of BRAF mutations in neoplasia was first recognized in 2002 when
mutations were discovered in a broad range of cancers. Numerous subsequent studies …

BRAF represents one of the most frequently mutated protein kinase genes in human
tumours. The mutation is commonly tested in pathology practice. BRAF mutation is seen in …

Context Accurate classification of follicular-patterned thyroid lesions is not always an easy
task on routine surgical hematoxylin-eosin–stained or cytologic fine-needle aspiration …

BRAF p. V600 mutation detection recently became necessary to treat metastatic melanoma
patients with vemurafenib. This study compares different methods of detection of BRAF …

BRAFV600E mutation in microsatellite-unstable (MSI) colorectal carcinomas (CRCs)
virtually excludes Lynch syndrome (LS). In microsatellite-stable (MSS) CRCs it predicts poor …

Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is an uncommon variant
of papillary thyroid carcinoma. The aim of this review is to critically analyse the features of …

The differentiation between hereditary and sporadic microsatellite‐unstable (MSI‐H)
colorectal cancer is a crucial step in Lynch syndrome diagnostics. Within MSI‐H colorectal …