Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Accumulating evidence over last several years indicates an important role of microglial cells
in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain …

Investigation of the basic mechanisms of chronic pain not only provides insights into how the
brain processes and modulates sensory information but also provides the basis for …

Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an
important target for nociceptive regulation at the spinal level. However, little is known about …

Emotional–affective and cognitive dimensions of pain are less well understood than
nociceptive and nocifensive components, but the forebrain is believed to play an important …

Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system.
Investigations have mainly focused on the spinal mechanisms of neuropathic pain, and less …

The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

Neuropathic pain is generally defined as a chronic pain state resulting from peripheral
and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part …

As the most common symptomatic reason to seek medical consultation, pain is a complex
experience that has been classified into different categories and stages. In pain processing …

Neuropathic pain is generally defined as a chronic pain state resulting from peripheral or
central nerve injury, or both. An effective treatment for neuropathic pain is still lacking. The …