Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment

S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

[HTML][HTML] Immunity to viruses

TJ Braciale, YS Hahn - Immunological reviews, 2013 - ncbi.nlm.nih.gov
Immunity to viruses - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI
Homepage MyNCBI Homepage Main Content Main Navigation Preview improvements coming …

Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment

M Spaan, G van Oord, K Kreefft, J Hou… - The Journal of …, 2016 - academic.oup.com
Background. Chronic hepatitis C virus (HCV) infection is a global health problem, resulting
in liver failure, hepatocellular carcinoma, and liver-related death. Natural killer (NK) cells are …

[HTML][HTML] An insight into the diagnosis and pathogenesis of hepatitis C virus infection

M Irshad, DS Mankotia, K Irshad - World journal of …, 2013 - ncbi.nlm.nih.gov
This review focuses on research findings in the area of diagnosis and pathogenesis of
hepatitis C virus (HCV) infection over the last few decades. The information based on …

Memory re‐differentiation and reduced lymphocyte activation in chronic HCV‐infected patients receiving direct‐acting antivirals

MA Burchill, L Golden‐Mason… - Journal of viral …, 2015 - Wiley Online Library
Recently, the treatment of HCV has advanced significantly due to the introduction of direct‐
acting antivirals (DAA s). Studies using interferon (IFN)‐containing regimens failed to …

Protective immunity against hepatitis C: many shades of gray

MS Abdel-Hakeem, NH Shoukry - Frontiers in immunology, 2014 - frontiersin.org
The majority of individuals who become acutely infected with hepatitis C virus (HCV)
develop chronic infection and suffer from progressive liver damage while approximately …

Hepatitis C virus–induced myeloid-derived suppressor cells suppress NK cell IFN-γ production by altering cellular metabolism via arginase-1

CC Goh, KM Roggerson, HC Lee… - The journal of …, 2016 - journals.aai.org
The hepatitis C virus (HCV) infects∼ 200 million people worldwide. The majority of infected
individuals develop persistent infection, resulting in chronic inflammation and liver disease …

Innate and adaptive immune responses in chronic HCV infection

LB Dustin - Current drug targets, 2017 - ingentaconnect.com
Hepatitis C virus (HCV) remains a public health problem of global importance, even in the
era of potent directly-acting antiviral drugs. In this chapter, I discuss immune responses to …

Indoleamine-2, 3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways

A Park, Y Yang, Y Lee, MS Kim, YJ Park… - Journal of clinical …, 2019 - mdpi.com
Natural killer (NK) cells are key players in the immune system. They use receptors on their
cell surface to identify target cells. However, to escape being killed by the immune system …

[HTML][HTML] Natural killer cells in hepatitis C: Current progress

JC Yoon, CM Yang, Y Song, JM Lee - World journal of …, 2016 - ncbi.nlm.nih.gov
Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of
chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular …