[HTML][HTML] Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo

AS Obozina, EN Komedchikova, OA Kolesnikova… - Pharmaceutics, 2023 - mdpi.com
Targeted nanoparticles of different origins are considered as new-generation diagnostic and
therapeutic tools. However, there are no targeted drug formulations within the composition of …

[HTML][HTML] Recent advances on Affibody-and DARPin-conjugated nanomaterials in cancer therapy

F Gabriele, M Palerma, R Ippoliti, F Angelucci… - International Journal of …, 2023 - mdpi.com
Affibodies and designed ankyrin repeat proteins (DARPins) are synthetic proteins originally
derived from the Staphylococcus aureus virulence factor protein A and the human ankyrin …

Internalization-responsive poly (lactic-co-glycolic acid) nanoparticles for image-guided photodynamic therapy against HER2-positive breast cancer

AS Sogomonyan, SM Deyev… - ACS Applied Nano …, 2023 - ACS Publications
Oncotheranostic nanoagents are powerful artificial tools that significantly outperform
traditional antitumor therapies. Among the wide variety of nanoagents, poly (lactic-co …

[HTML][HTML] Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One …

VO Shipunova, EN Komedchikova, PA Kotelnikova… - Pharmaceutics, 2023 - mdpi.com
Therapy for aggressive metastatic breast cancer remains a great challenge for modern
biomedicine. Biocompatible polymer nanoparticles have been successfully used in clinic …

Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases

EN Komedchikova, OA Kolesnikova, AV Syuy… - Journal of Controlled …, 2024 - Elsevier
Developing combined cancer therapy strategies is of utmost importance as it can enhance
treatment efficacy, overcome drug resistance, and ultimately improve patient outcomes by …

[HTML][HTML] Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase: Barstar Pair

LG Alekseeva, OV Ovsyanikova, AA Schulga… - Cells, 2024 - mdpi.com
(1) Background: We have previously shown that the use of an artificial supramolecular two-
component system based on chimeric recombinant proteins 4D5scFv-barnase and barstar …

[HTML][HTML] Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents

VL Kovalenko, OA Kolesnikova, MP Nikitin… - Micromachines, 2023 - mdpi.com
Photothermal therapy is one of the most promising and rapidly developing fields in modern
oncology due to its high efficiency, localized action, and minimal invasiveness. Polymeric …

The influence of various polymer coatings on the in vitro and in vivo properties of PLGA nanoparticles: Comprehensive study

AM Iureva, PI Nikitin, ED Tereshina, MP Nikitin… - European Journal of …, 2024 - Elsevier
Nanoparticles based on poly (lactic-co-glycolic acid)(PLGA) with various surface chemistry
are widely used in biomedicine for theranostic applications. The nature of the external …

Internalization-Responsive Nano-PLGA For Image-Guided Photodynamic Therapy Against HER2-Positive Breast Cancer

AS Sogomonyan, SM Deyev, VO Shipunova - bioRxiv, 2023 - biorxiv.org
Oncotheranostic nanoagents are powerful artificial compounds that significantly outperform
traditional antitumor therapies. Among the wide variety of nanoagents, polymer …