The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Sjögren's syndrome (SS) is a chronic autoimmune disease with the pathological hallmark of
lymphoplasmacytic infiltration of exocrine glands-more specifically salivary and lacrimal …

As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the
normal physiological functions of ocular tissues. This review provides an overview of the …

Aging is the most important known risk factor for dry eye is aging, which is associated with
changes in the structure and function of the lacrimal gland (LG) and characterized by …

Purpose: The purpose of this study was to determine whether rodent lacrimal glands (LGs)
represent a suitable surrogate for human tissue in bio-engineering research, we undertook a …

Purpose: Dry eye syndrome (DES) is a prevalent postoperative complication after myopic
corneal refractive surgeries and the main cause of postoperative dissatisfaction. Although …

Purpose: Dry eye disease (DED) is multifactorial and associated with nerve abnormalities.
We explored an Aquaporin 5 (AQP5)-deficiency-induced JunB activation mechanism, which …

Diabetes mellitus is a prevalent disease that is often accompanied by ocular surface
abnormalities including delayed epithelial wound healing and decreased corneal sensitivity …

The lacrimal gland is responsible for maintaining the health of the ocular surface through the
production of tears. However, our understanding of the immune system within the lacrimal …

Purpose To investigated the role of estrogen receptor-1 (ER-1) in maintaining homeostasis
in ocular surface. Methods ER-1-knockout (ER-1KO) mice were studied at 4 months of age …