Midazolam is a commonly used benzodiazepine in palliative care and is considered one of
the four essential drugs needed for the promotion of quality care in dying patients. Acting on …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

Precision medicine is a growing field in critical care. Research increasingly demonstrated
pharmacogenomic variability to be an important determinant of analgesic and sedative drug …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Recent advances in technology and better understanding of mechanisms underlying
disease are beginning to enable us to better characterize critically ill patients. Instead of …

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia
induced by drugs including opioids, hypnotic-sedative agents, muscle relaxants and …

Over the past decade, pharmacogenetics (PGx) became an essential tool for personalized
medicine although its clinical implementation is still limited. We aimed to assess the current …

Background Pharmacogenetics could represent a further resource to understand the
interindividual heterogeneity of response of the host to sepsis and to provide a personalized …

Objective The objective of this review is to discuss the therapeutic use and differential
treatment response to Levo‐carnitine (l‐carnitine) treatment in septic shock, and to …