The shortly upcoming 5th edition of the World Health Organization Classification of Tumors
of the Central Nervous System is bringing extensive changes in the terminology of diffuse …

Glioblastoma remains as the most common and aggressive primary adult brain tumor to
date. Within the last decade, cancer immunotherapy surfaced as a broadly successful …

Over the past decade, remarkable progress has been made towards elucidating the origin
and genomic landscape of childhood high-grade brain tumours. It has become evident that …

In glioblastoma with typical immunosuppressive characteristics, immune checkpoint
inhibitors treatment showed unsatisfactory clinical effects, attributable to the exclusion of …

Tremendous success using CAR T therapy in hematological malignancies has garnered
significant interest in developing such treatments for solid tumors, including brain tumors …

Medulloblastoma is the most common malignant brain tumor in children. Over the last few
decades, significant progress has been made in revealing the key molecular underpinnings …

The overall survival of pediatric gliomas varies over a wide spectrum depending on the
tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible …

Pediatric high-grade gliomas (pHGGs) are a group of tumors affecting approximately 0.85
children per 100,000 annually. The general outcome for these tumors is poor with 5-year …

Brain tumors are the most common solid tumors in children and are associated with high
mortality. The most common childhood brain tumors are grouped as low-grade gliomas …

Simple Summary Medulloblastoma (MB) is a primary brain tumor and is one of the most
prevalent neoplasms in the pediatric age group, with a median age of diagnosis of six years …