One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The
members of this large family of membrane proteins are activated by a spectrum of …

G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and
are important drug targets. Their diverse signaling pathways are driven by complex …

Conformational selection and induced fit are two prevailing mechanisms, to explain the
molecular basis for ligand-based activation of receptors. G-protein-coupled receptors are the …

Adenosine receptors and β-adrenoceptors are G-protein-coupled receptors (GPCRs) that
activate intracellular G proteins on binding the agonists adenosine or noradrenaline …

Multidrug resistance in cancer is linked to expression of the P-glycoprotein multidrug
transporter (Pgp, ABCB1), which exports many structurally diverse compounds from cells …

After decades of slow progress, the pace of research on membrane protein structures is
beginning to quicken thanks to various improvements in technology, including protein …

There are≈ 350 non-odorant G protein-coupled receptors (GPCRs) encoded by the human
genome, many of which are predicted to be potential therapeutic targets, but there are only …

The membrane bilayer has a significant influence over the proteins embedded within it. G
protein-coupled receptors (GPCRs) form a large group of membrane proteins with a vast …

Functional and structural studies of membrane proteins usually require overexpression of
the proteins in question. Often, however, the 'trial and error'approaches that are mainly used …