Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction
and a major proapoptotic member of the B‐cell lymphoma 2 (Bcl‐2) family proteins that …

Background: Whether statin type influences hepatocellular carcinoma (HCC) incidence or
mortality in chronic hepatitis B or C virus infection is unknown. Objective: To assess the …

Importance Patients with cancer who use statins appear to have a substantially better
survival than nonusers in observational studies. However, this inverse association between …

Nonalcoholic fatty liver disease (NAFLD) is now the most common liver disease in the
United States, with more than 80 million Americans affected. It represents a spectrum of …

Aims Nephrotoxicity is the hallmark of anti-neoplastic drug metabolism that causes oxidative
stress. External chemical agents and prescription drugs release copious amounts of free …

The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

Abstract Statins [3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase,
abbreviated HMGCR) inhibitors], are well-known cholesterol-depleting agents. Since the …

In this review we introduce the concept of the tumor macroenvironment and explore it in the
context of metabolism. Tumor cells interact with the tumor microenvironment including …