[HTML][HTML] Statins attenuate outgrowth of breast cancer metastases
Background Metastasis in breast cancer foreshadows mortality, as clinically evident disease
is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a …
is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a …
Niosomal delivery of simvastatin to MDA-MB-231 cancer cells
Objective The objective of this study was to use nano-niosomal formulations to deliver
simvastatin as a poor-water soluble drug into breast cancer cells. Significance Our study …
simvastatin as a poor-water soluble drug into breast cancer cells. Significance Our study …
[HTML][HTML] Impact of atorvastatin loaded exosome as an anti-glioblastoma carrier to induce apoptosis of U87 cancer cells in 3D culture model
Exosomes (EXOs) are naturally occurring nanosized lipid bilayers that can be efficiently
used as a drug delivery system to carry small pharmaceutical, biological molecules and …
used as a drug delivery system to carry small pharmaceutical, biological molecules and …
[HTML][HTML] Paradoxical effects of statins on endothelial and cancer cells: The impact of concentrations
In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on
apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these …
apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these …
Association of statin use with clinical outcomes in patients with triple‐negative breast cancer
MK Nowakowska, X Lei, MT Thompson… - Cancer, 2021 - Wiley Online Library
Background Previous studies have examined the association of statin therapy and breast
cancer outcomes with mixed results. The objective of this study was to investigate the clinical …
cancer outcomes with mixed results. The objective of this study was to investigate the clinical …
[HTML][HTML] Simvastatin induces apoptosis in medulloblastoma brain tumor cells via mevalonate cascade prenylation substrates
K Sheikholeslami, A Ali Sher, S Lockman, D Kroft… - Cancers, 2019 - mdpi.com
Medulloblastoma is a common pediatric brain tumor and one of the main types of solid
cancers in children below the age of 10. Recently, cholesterol-lowering “statin” drugs have …
cancers in children below the age of 10. Recently, cholesterol-lowering “statin” drugs have …
Potentiating the cytotoxic activity of a novel simvastatin-loaded cubosome against breast cancer cells: insights on dual cell death via ferroptosis and apoptosis
YE Elakkad, SNS Mohamed… - Breast cancer: targets …, 2021 - Taylor & Francis
Purpose Female breast cancer is the most prevalent cancer worldwide. Emerging evidence
shows that simvastatin (SIM) has promising anticancer activities. However, the underlying …
shows that simvastatin (SIM) has promising anticancer activities. However, the underlying …
Efficacy and safety of statin for hepatocellular carcinoma prevention among chronic liver disease patients: a systematic review and meta-analysis
Methods: We performed a systematic search of 4 electronic databases (PubMed/MEDLINE,
EMBASE, Cochrane library, and ClinicalTrial. gov) up to April 15, 2020. We selected all …
EMBASE, Cochrane library, and ClinicalTrial. gov) up to April 15, 2020. We selected all …
Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress
J Yang, Z Wang, DL Chen - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Shikonin, isolated from the roots of herbal plant Lithospermum erythrorhizon, is a
naphthoquinone. It has been reported to exert beneficial anti-inflammatory effects and anti …
naphthoquinone. It has been reported to exert beneficial anti-inflammatory effects and anti …
Statins, Bcl-2, and apoptosis: cell death or cell protection?
WG Wood, U Igbavboa, WE Muller, GP Eckert - Molecular neurobiology, 2013 - Springer
Statins have proven their effectiveness in the treatment of cardiovascular disease. This class
of drugs has also attracted attention as a potential treatment for dissimilar diseases such as …
of drugs has also attracted attention as a potential treatment for dissimilar diseases such as …