Drug resistance to temozolomide (TMZ) contributes to the majority of tumor recurrence and
treatment failure in patients with glioblastoma multiforme (GBM). Autophagy has been …

Background: Statins purportedly exert antitumoral effects, but the underlying mechanisms
are currently not fully elucidated. The aim of this study was to explore potential statin …

Background Statin therapy has been shown to reduce mortality in a wide range of cancer
types and overall stages. Still, there is uncertainty about its efficacy in increasing survival …

Hepatocellular carcinoma (HCC) is a common, treatment‐resistant malignancy with a
complex molecular pathogenesis. Statins are a widely used class of cholesterol‐lowering …

Pancreatic ductal adenocarcinoma (PDA) has poor therapeutic options. Recent patient
studies indicate that cholesterol-lowering statins have anti-tumor capacities. We examined …

Aims In this study, we investigated whether statins induce human cholangiocarcinoma
(CCA) cell death and apoptosis, and examined the mechanism by which statins act on cells …

We examined the anti-cancer effects and molecular mechanism of simvastatin in human
castration-resistant prostate cancer (CRPC) cells, particularly focused on LIN28B and its …

Solid tumor growth triggers a dynamic host response, which recapitulates wound healing
and defines the tumor microenvironment (TME). In addition to the action of the tumor cells …

Liver cancer has a high incidence and mortality rate worldwide, with hepatocellular
carcinoma (HCC) being the most common histological type. With the decrease in the …

Osteosarcoma is the leading primary bone cancer in young adults and exhibits high
chemoresistance rates. Therefore, characterization of both alternative treatment options and …