Management of hepatocellular carcinoma in Japan: JSH consensus statements and recommendations 2021 update

M Kudo, Y Kawamura, K Hasegawa, R Tateishi… - Liver cancer, 2021 - karger.com
Abstract The Clinical Practice Manual for Hepatocellular Carcinoma was published based
on evidence confirmed by the Evidence-based Clinical Practice Guidelines for …

[HTML][HTML] Combination therapy for advanced hepatocellular carcinoma: do we see the light at the end of the tunnel?

T Zhang, P Merle, H Wang, H Zhao… - … surgery and nutrition, 2021 - ncbi.nlm.nih.gov
Combination therapy for advanced hepatocellular carcinoma: do we see the light at the end
of the tunnel? - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma

CG Kim, C Kim, SE Yoon, KH Kim, SJ Choi, B Kang… - Journal of …, 2021 - Elsevier
Background & Aims Programmed cell death-1 (PD-1) inhibitor treatment can cause
hyperprogressive disease (HPD), but the incidence, outcome, and predictive factors of HPD …

[PDF][PDF] Achievement of complete response and drug-free status by atezolizumab plus bevacizumab combined with or without curative conversion in patients with …

M Kudo, T Aoki, K Ueshima, K Tsuchiya, M Morita… - Liver cancer, 2023 - karger.com
Introduction: Atezolizumab plus bevacizumab therapy is extremely effective in the treatment
of intermediate-stage hepatocellular carcinoma (HCC), with a response rate of 44%, as …

[HTML][HTML] Durvalumab plus tremelimumab in unresectable hepatocellular carcinoma

M Kudo - Hepatobiliary surgery and nutrition, 2022 - ncbi.nlm.nih.gov
The results of the Phase 3 HIMALAYA trial were presented at ASCO-GI 2022 (1).
Durvalumab+ tremelimumab (Durva/Treme) has also been approved for the treatment of …

[HTML][HTML] A novel treatment strategy for patients with intermediate-stage HCC who are not suitable for TACE: upfront systemic therapy followed by curative conversion

M Kudo - Liver cancer, 2021 - karger.com
Upfront systemic therapy with subsequent locoregional therapy is a new therapeutic option
for intermediate-stage hepatocellular carcinoma (HCC). The first example of such treatment …

Serum concentration of CD137 and tumor infiltration by M1 macrophages predict the response to sintilimab plus bevacizumab biosimilar in advanced hepatocellular …

W Zhang, C Gong, X Peng, X Bi, Y Sun, J Zhou… - Clinical Cancer …, 2022 - AACR
Purpose: This study aimed to investigate the biomarkers of sintilimab (anti–PD-1) plus
IBI305 (a bevacizumab biosimilar) in advanced hepatocellular carcinoma (HCC), as well as …

Atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma: Early clinical experience

A Hiraoka, T Kumada, T Tada, M Hirooka… - Cancer …, 2022 - Wiley Online Library
Background Although atezolizumab plus bevacizumab (Atez/bev) treatment has been
developed for unresectable hepatocellular carcinoma (u‐HCC), changes in hepatic function …

Atezolizumab and bevacizumab combination compared with sorafenib as the first‐line systemic treatment for patients with unresectable hepatocellular carcinoma: a …

F Wen, H Zheng, P Zhang, W Liao, K Zhou… - Liver …, 2021 - Wiley Online Library
Abstract Background & Aims In patients with unresectable hepatocellular carcinoma (HCC),
the combination of atezolizumab and bevacizumab improved progression‐free survival …

[HTML][HTML] Clinically approved combination immunotherapy: Current status, limitations, and future perspective

L Lu, M Zhan, XY Li, H Zhang, DJ Dauphars… - Current research in …, 2022 - Elsevier
Immune-checkpoint inhibitor-based combination immunotherapy has become a first-line
treatment for several major types of cancer including hepatocellular carcinoma (HCC), renal …