Early detection of cancer has held great promise and intuitive appeal in the medical
community for well over a century. Its history developed in tandem with that of the periodic …

At the present time, lung cancer is the leading cause of cancer-related death in males.
Diagnostic difficulty makes detection complicated and this, in conjunction with the low …

Abstract Each year the American Cancer Society publishes a summary of existing
recommendations for early cancer detection, including updates, and/or emerging issues that …

Abstract Background: The Mayo Lung Project (MLP) was a randomized, controlled clinical
trial of lung cancer screening that was conducted in 9211 male smokers between 1971 and …

Background Obstructive lung disease and lung cancer are tobacco-related diseases that
can remain clinically silent until late in the disease process. We sought to define the risk for …

Objective The purpose of this study was to determine the relationship between tumor size
and survival in patients with stage IA non-small cell lung cancer (non-small cell lung cancer; …

Since the publication of the first mortality results from the National Lung Screening Trial
(NLST), which showed a 20% reduction in lung-cancer mortality with low-dose computed …

BACKGROUND The study was launched in the mid‐1970s to explore the capability of
screening by chest X‐ray and sputum cytology to be used as an effective component of the …

The concept of early detection of cancer holds great promise and intuitive appeal. However,
powerful biases can mislead clinicians when evaluating the efficacy of screening tests by …

BACKGROUND Skepticism about the radical curability of lung carcinoma, even when
diagnosed in Stage I, has been long fostered by the epidemiologists' dogma against lung …