Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

Animal models have been used extensively in diabetes research. Early studies used
pancreatectomised dogs to confirm the central role of the pancreas in glucose homeostasis …

Previous studies showed a low-grade enterovirus infection in the pancreatic islets of patients
with newly diagnosed type 1 diabetes (T1D). In the Diabetes Virus Detection (DiViD) …

Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes
mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death …

Inflammatory infiltrate of mononuclear cells in an islet from a 2-yearold patient with type 1
diabetes of short duration. Mononuclear cells in and around islets are shown by yellow …

Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are
believed to be a major component for the development of type 1diabetes, but the …

Viruses have long been considered a major environmental factor in the aetiology of Type I
(insulin-dependent) diabetes mellitus and recent work has greatly confirmed and extended …

Type 1 diabetes is an autoimmune condition that results from the destruction of the insulin-
producing beta cells of the pancreas. The excess morbidity and mortality resulting from its …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Fulminant type 1 diabetes is a recently discovered subtype of type 1 diabetes. It is defined as
diabetes in which the process of β-cell destruction and the progression of hyperglycemia …