Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …

The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …

G protein‐coupled receptors (GPCRs) are membrane‐bound proteins that are ubiquitously
expressed in many cell types and take part in mediating multiple signaling pathways …

Toxoplasmosis is caused by Toxoplasma gondii and in immunocompromised patients it may
lead to seizures, encephalitis or death. The conserved enzyme prolyl-tRNA synthetase …

The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product,
is rapidly expanding. Consequently, there is an urgent requirement for an environment …

The RORγt nuclear receptor (NR) is of critical importance for the differentiation and
proliferation of T helper 17 (Th17) cells and their production of the pro-inflammatory cytokine …

Although multiple components of the cell membrane modulate the stability and activation of
G protein-coupled receptors (GPCRs), insights into the dynamics of GPCR structures come …

Cooperative interactions in protein-protein interfaces demonstrate the interdependency or
the linked network-like behavior and their effect on the coupling of proteins. Cooperative …

ER/K α-helices are a subset of single alpha helical domains, which exhibit unusual stability
as isolated protein secondary structures. They adopt an elongated structural conformation …

The eukaryotic kinase domain has multiple intrinsically disordered regions whose
conformation dictates kinase activity. Small molecule kinase inhibitors (SMKIs) rely on …