Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
SG Sarafianos, K Das, AD Clark Jr… - Proceedings of the …, 1999 - National Acad Sciences
An important component of triple-drug anti-AIDS therapy is 2′, 3′-dideoxy-3′-thiacytidine
(3TC, lamivudine). Single mutations at residue 184 of the reverse transcriptase (RT) in HIV …
(3TC, lamivudine). Single mutations at residue 184 of the reverse transcriptase (RT) in HIV …
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
J Ding, K Das, H Moereels, L Koymans… - Nature structural …, 1995 - nature.com
We report the structure of HIV-1 reverse transcriptase (RT) complexed with the
nonnucleoside inhibitor TIBO R 86183 at 3.0 Å resolution. Comparing this structure with …
nonnucleoside inhibitor TIBO R 86183 at 3.0 Å resolution. Comparing this structure with …
[PDF][PDF] Comparative quantitative structure− activity relationship studies on anti-HIV drugs
R Garg, SP Gupta, H Gao, MS Babu… - Chemical …, 1999 - researchgate.net
In the present era, acquired immunodeficiency syndrome (AIDS) is the most fatal disorder for
which no completely successful chemotherapy has been developed so far. The pandemic …
which no completely successful chemotherapy has been developed so far. The pandemic …
Hormonal control of T-cell development in health and disease
The physiology of the thymus, the primary lymphoid organ in which T cells are generated, is
controlled by hormones. Data from animal models indicate that several peptide and …
controlled by hormones. Data from animal models indicate that several peptide and …
[HTML][HTML] Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 …
Drug resistance is a key cause of failure for treatment of HIV infection. The efficacy of non-
nucleoside reverse transcriptase inhibiting (NNRTI) drugs is impaired by rapid emergence of …
nucleoside reverse transcriptase inhibiting (NNRTI) drugs is impaired by rapid emergence of …
Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors
The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and
there is evidence for its spread to Europe and Asia. HIV-2 reverse transcriptase (RT) …
there is evidence for its spread to Europe and Asia. HIV-2 reverse transcriptase (RT) …
Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant
K Das, J Ding, Y Hsiou, AD Clark Jr, H Moereels… - Journal of molecular …, 1996 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is an important
target for chemotherapeutic agents used in the treatment of AIDS; the TIBO compounds are …
target for chemotherapeutic agents used in the treatment of AIDS; the TIBO compounds are …
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis (heteroaryl) piperazine (BHAP) U-90152 explain resistance mutations …
RM Esnouf, J Ren, AL Hopkins… - Proceedings of the …, 1997 - National Acad Sciences
The viral reverse transcriptase (RT) provides an attractive target in the search for anti-HIV
therapies. The nonnucleoside inhibitors (NNIs) are a diverse set of compounds (usually HIV …
therapies. The nonnucleoside inhibitors (NNIs) are a diverse set of compounds (usually HIV …
The HIV‐1 reverse transcription (RT) process as target for RT inhibitors
H Jonckheere, J Anné… - Medicinal research reviews, 2000 - Wiley Online Library
Abstract Since the Human Immunodeficiency Virus Type 1 (HIV‐1) was identified as the
etiologic agent of the Acquired Immune Deficiency Syndrome (AIDS), the HIV‐1 reverse …
etiologic agent of the Acquired Immune Deficiency Syndrome (AIDS), the HIV‐1 reverse …
Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding
Nonnucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic
compounds with diverse structures that specifically inhibit HIV-1 reverse transcriptase (RT) …
compounds with diverse structures that specifically inhibit HIV-1 reverse transcriptase (RT) …