An important component of triple-drug anti-AIDS therapy is 2′, 3′-dideoxy-3′-thiacytidine
(3TC, lamivudine). Single mutations at residue 184 of the reverse transcriptase (RT) in HIV …

We report the structure of HIV-1 reverse transcriptase (RT) complexed with the
nonnucleoside inhibitor TIBO R 86183 at 3.0 Å resolution. Comparing this structure with …

In the present era, acquired immunodeficiency syndrome (AIDS) is the most fatal disorder for
which no completely successful chemotherapy has been developed so far. The pandemic …

The physiology of the thymus, the primary lymphoid organ in which T cells are generated, is
controlled by hormones. Data from animal models indicate that several peptide and …

Drug resistance is a key cause of failure for treatment of HIV infection. The efficacy of non-
nucleoside reverse transcriptase inhibiting (NNRTI) drugs is impaired by rapid emergence of …

The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and
there is evidence for its spread to Europe and Asia. HIV-2 reverse transcriptase (RT) …

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is an important
target for chemotherapeutic agents used in the treatment of AIDS; the TIBO compounds are …

The viral reverse transcriptase (RT) provides an attractive target in the search for anti-HIV
therapies. The nonnucleoside inhibitors (NNIs) are a diverse set of compounds (usually HIV …

Abstract Since the Human Immunodeficiency Virus Type 1 (HIV‐1) was identified as the
etiologic agent of the Acquired Immune Deficiency Syndrome (AIDS), the HIV‐1 reverse …

Nonnucleoside reverse transcriptase inhibitors (NNRTI) are a group of small hydrophobic
compounds with diverse structures that specifically inhibit HIV-1 reverse transcriptase (RT) …