[HTML][HTML] Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases: structural and biochemical analyses
Most non-nucleoside reverse transcriptase (RT) inhibitors are specific for HIV-1 RT and
demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the …
demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the …
[HTML][HTML] Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase
MM Georgiadis, SM Jessen, CM Ogata, A Telesnitsky… - Structure, 1995 - cell.com
Background: Reverse transcriptase (RT) converts the single-stranded RNA genome of a
retrovirus into a double-stranded DNA copy for integration into the host genome. This …
retrovirus into a double-stranded DNA copy for integration into the host genome. This …
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1
J Guillemont, E Pasquier, P Palandjian… - Journal of medicinal …, 2005 - ACS Publications
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY)
compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis …
compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis …
Structural basis for the inhibitory efficacy of efavirenz (DMP‐266), MSC194 and PNU142721 towards the HIV‐1 RT K103N mutant
J Lindberg, S Sigurðsson, S Löwgren… - European Journal of …, 2002 - Wiley Online Library
The K103N substitution is a frequently observed HIV‐1 RT mutation in patients who do not
respond to combination‐therapy. The drugs Efavirenz, MSC194 and PNU142721 belong to …
respond to combination‐therapy. The drugs Efavirenz, MSC194 and PNU142721 belong to …
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
J Balzarini - Current topics in medicinal chemistry, 2004 - ingentaconnect.com
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor
(NNRTI) lead compounds have been discovered. Nowadays, three NNRTIs are approved for …
(NNRTI) lead compounds have been discovered. Nowadays, three NNRTIs are approved for …
Inhibition of HIV-1 by fusion inhibitors
D Eggink, B Berkhout… - Current pharmaceutical …, 2010 - ingentaconnect.com
The envelope glycoprotein complex (Env) is responsible for entry of the human
immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and …
immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and …
Reverse transcription of retroviruses and LTR retrotransposons
SH Hughes - Mobile DNA III, 2015 - Wiley Online Library
The conversion, well over a billion years ago, of the RNA world into the modern
configuration, in which genetic information is maintained primarily in DNA, required reverse …
configuration, in which genetic information is maintained primarily in DNA, required reverse …
[HTML][HTML] HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro
JA Grobler, G Dornadula, MR Rice, AL Simcoe… - Journal of Biological …, 2007 - ASBMB
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent
allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase …
allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase …
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants
AL Hopkins, J Ren, H Tanaka, M Baba… - Journal of medicinal …, 1999 - ACS Publications
Two analogues of the nonnucleoside inhibitor of HIV-1 RT, MKC-442 (emivirine), containing
different C6 substituents have been designed to be less susceptible to the commonly found …
different C6 substituents have been designed to be less susceptible to the commonly found …
Delavirdine: a review of its use in HIV infection
LJ Scott, CM Perry - Drugs, 2000 - Springer
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with us Track your research Search Cart 1.Home 2.Drugs 3.Article Delavirdine A Review of its …
with us Track your research Search Cart 1.Home 2.Drugs 3.Article Delavirdine A Review of its …