Most non-nucleoside reverse transcriptase (RT) inhibitors are specific for HIV-1 RT and
demonstrate minimal inhibition of HIV-2 RT. However, we report that members of the …

Background: Reverse transcriptase (RT) converts the single-stranded RNA genome of a
retrovirus into a double-stranded DNA copy for integration into the host genome. This …

This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY)
compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis …

The K103N substitution is a frequently observed HIV‐1 RT mutation in patients who do not
respond to combination‐therapy. The drugs Efavirenz, MSC194 and PNU142721 belong to …

Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor
(NNRTI) lead compounds have been discovered. Nowadays, three NNRTIs are approved for …

The envelope glycoprotein complex (Env) is responsible for entry of the human
immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and …

The conversion, well over a billion years ago, of the RNA world into the modern
configuration, in which genetic information is maintained primarily in DNA, required reverse …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent
allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase …

Two analogues of the nonnucleoside inhibitor of HIV-1 RT, MKC-442 (emivirine), containing
different C6 substituents have been designed to be less susceptible to the commonly found …

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with us Track your research Search Cart 1.Home 2.Drugs 3.Article Delavirdine A Review of its …