1-[2-(2-Benzoyl-and 2-benzylphenoxy) ethyl] uracils as potent anti-HIV-1 agents
Non-nucleoside reverse transcriptase inhibitors (NNRTI) are key components in highly
active antiretroviral therapy for treating HIV-1. Herein we present the synthesis for a series of …
active antiretroviral therapy for treating HIV-1. Herein we present the synthesis for a series of …
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097
K Das, SG Sarafianos, AD Clark Jr, PL Boyer… - Journal of molecular …, 2007 - Elsevier
Lys103Asn and Tyr181Cys are the two mutations frequently observed in patients exposed to
various non-nucleoside reverse transcriptase inhibitor drugs (NNRTIs). Human …
various non-nucleoside reverse transcriptase inhibitor drugs (NNRTIs). Human …
[图书][B] DNA Polymerases: Discovery, characterization and functions in cellular DNA transactions
U Hübscher - 2010 - books.google.com
Maintenance of the information embedded in the genomic DNA sequence is essential for
life. DNA polymerases play pivotal roles in the complex physiological processes of DNA …
life. DNA polymerases play pivotal roles in the complex physiological processes of DNA …
[PDF][PDF] HIV-1 fitness: implications for drug resistance, disease progression, and global epidemic evolution
ME Quiñones-Mateu, EJ Arts - HIV sequence compendium, 2001 - mit.edu
In the past five years, the HIV research field has shown renewed interest in the replicative
capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex …
capacity of human immunodeficiency virus type 1 (HIV-1) due to the potential impact of ex …
Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors
Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse
transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been …
transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been …
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single …
The kinetic parameters governing the inhibition by Nevirapine of the RNA-dependent DNA
synthesis catalyzed by HIV-1 reverse transcriptase have been determined by steady-state …
synthesis catalyzed by HIV-1 reverse transcriptase have been determined by steady-state …
Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of …
RH Archer, C Dykes, P Gerondelis, A Lloyd… - Journal of …, 2000 - Am Soc Microbiol
Three mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase
(V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to …
(V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to …
[HTML][HTML] The genetic basis of HIV-1 resistance to reverse transcriptase and protease inhibitors
RW Shafer, R Kantor, MJ Gonzales - AIDS reviews, 2000 - ncbi.nlm.nih.gov
HIV-1 drug resistance is caused by mutations in the reverse transcriptase (RT) and protease
enzymes, the molecular targets of antiretroviral therapy. At the beginning of the year 2000 …
enzymes, the molecular targets of antiretroviral therapy. At the beginning of the year 2000 …
Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants
EJ Lien, A Das, P Nandy, S Ren, H Kleinkauf… - Progress in Drug …, 1997 - Springer
Since a first version of this article on the relevance of quasispecies to viral disease control
was published by one of us [1], an explosion of information on viral quasispecies has been …
was published by one of us [1], an explosion of information on viral quasispecies has been …
Virus fitness: concept, quantification, and application to HIV population dynamics
ME Quinones-Mateu, EJ Arts - Quasispecies: Concept and Implications for …, 2006 - Springer
Viral fitness has been broadly studied during the past three decades, mainly to test
evolutionary models and population theories difficult to analyze and interpret with more …
evolutionary models and population theories difficult to analyze and interpret with more …