Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy.
Previous work revealed the importance of tumor‐derived excitatory glutamate (Glu) release …

The glutamate transporter xCT (SCL7a11, system Xc-, SXC) is an emerging key player in
glutamate/cysteine/glutathione homeostasis in the brain and in cancer. xCT expression …

Oncogenic signaling in cancer cells alters glucose uptake and utilization to supply sufficient
energy and biosynthetic intermediates for survival and sustained proliferation. Oncogenic …

We aimed to detect the functions of miR‐375/SLC7A11 axis on oral squamous cell
carcinoma (OSCC) cell proliferation and invasion. Expression levels of miR‐375 and …

Microglial cells in the brain tumor microenvironment are associated with enhanced glioma
malignancy. They persist in an immunosuppressive M2 state at the peritumoral site and …

The glutamate exchanger xCT (SLC7a11) is causally linked with the malignancy grade of
brain tumors and represents a key player in glutamate, cystine and glutathione metabolism …

Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …

Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is
often necessary. While clinical guidelines recommend all approved anticonvulsants, so far it …

Malfunctioning of system xc–, responsible for exchanging intracellular glutamate for
extracellular cystine, can cause oxidative stress and excitotoxicity, both important …

Background Glioblastoma multiforme is the most common lethal brain tumor in human
adults, with no major therapeutic breakthroughs in recent decades. Research is based …