The protective effect of N-acetylcysteine (NAC) and genistein (GEN) on an experimental
model of indomethacin (IND)-induced gastric injury was investigated. A total of 50 male rats …

Although recent study has shown tricin 4′-O-(threo-β-guaiacylglyceryl) ether (TTGE), an
isolated compound from Njavara rice, to have the most potent anti-inflammatory effects, the …

Nitric oxide as a therapeutic approach to the treatment of cardiovascular diseases attracted
the attention of researchers at the end of the 19th century. As a vasodilator, nitric oxide may …

Extracellular histones are mediators of inflammation, tissue injury and organ dysfunction.
Interactions between circulating histones and vascular endothelial cells are key events in …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Septic shock, the most common form of vasodilatory shock, is a subset of sepsis in …

Background Rheumatoid arthritis (RA) is a chronic inflammatory disorder causing cartilage
and joint degeneration. In spite of the availability of several robust drugs like biologics, most …

Abstract Angiotensin-(1–7)[Ang-(1–7)] exhibits blood pressure lowering actions, inhibits cell
growth, and reduces tissue inflammation and fibrosis which may functionally antagonize an …

Wound repair is regulated by overlapping cellular, physiological and biochemical events.
Prostaglandins and nitric oxide have been a focus for inflammation research particularly …

Sildenafil (SIL) has potential as an interesting gastroprotective drug. However, the pathways
of its protective effect still needs to be clarified, and its use as a potential gastroprotective …

Caffeine is the most widely used psychotropic drug in the world. Most of the caffeine
consumed comes from coffee bean (ie, a misnomer for the seed of Coffea plants), beverages …