The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

The lipid endocannabinoid system refers to endogenous cannabinoids (eCBs), the enzymes
involved in their synthesis and metabolism, and the G protein-coupled cannabinoid …

Summary Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in
multiple forms of pediatric epilepsies, but the mechanism (s) of anti-seizure action remain …

In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially
expressed in axons where it has a unique property, namely resistance to agonist-driven …

The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as
CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses …

Sleep deprivation is commonplace in modern society, Short periods of continuous sleep
deprivation (SD) may negatively affect brain and behavioral function and may lead to vehicle …

Alternative splicing can often result in the expression of distinct protein isoforms from a
single gene, with specific composition and properties. SH3-containing GRB2-like protein 3 …

Sexual dimorphisms are observed in cannabinoid pharmacology. It is widely reported that
female animals are more sensitive to the cataleptic, hypothermic, antinociceptive, and anti …

The therapeutic effects of electroacupuncture (EA) on the comorbidity of visceral pain and
anxiety in patients with inflammatory bowel disease (IBD) is well known. It has been known …