Mustard gas toxicity: the acute and chronic pathological effects

K Ghabili, PS Agutter, M Ghanei… - Journal of applied …, 2010 - Wiley Online Library
Ever since it was first used in armed conflict, mustard gas (sulfur mustard, MG) has been
known to cause a wide range of acute and chronic injuries to exposure victims. The earliest …

Historical perspective on effects and treatment of sulfur mustard injuries

JS Graham, BA Schoneboom - Chemico-biological interactions, 2013 - Elsevier
Abstract Sulfur mustard (2, 2′-dichlorodiethyl sulfide; SM) is a potent vesicating chemical
warfare agent that poses a continuing threat to both military and civilian populations …

Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries

SNS Anumolu, AR Menjoge, M Deshmukh, D Gerecke… - Biomaterials, 2011 - Elsevier
Doxycycline hydrogels containing reversible disulfide crosslinks were investigated for a
dermal wound healing application. Nitrogen mustard (NM) was used as a surrogate to mimic …

[HTML][HTML] Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy

V Paromov, Z Suntres, M Smith… - Journal of burns and …, 2007 - ncbi.nlm.nih.gov
Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military
code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin …

Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and …

D Kumar, N Tewari-Singh, C Agarwal, AK Jain, S Inturi… - Toxicology letters, 2015 - Elsevier
Our recent studies in SKH-1 hairless mice have demonstrated that topical exposure to
nitrogen mustard (NM), an analog of sulfur mustard (SM), triggers the inflammatory …

[HTML][HTML] Sulfur mustard research—strategies for the development of improved medical therapy

K Kehe, F Balszuweit, J Emmler, H Kreppel, M Jochum… - Eplasty, 2008 - ncbi.nlm.nih.gov
Objective: Sulfur mustard (SM) is a bifunctional alkylating substance being used as chemical
warfare agent (vesicant). It is still regarded as a significant threat in chemical warfare and …

Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice

A Pal, N Tewari-Singh, M Gu, C Agarwal… - Free Radical Biology …, 2009 - Elsevier
A monofunctional analog of the chemical warfare agent sulfur mustard (HD), 2-chloroethyl
ethyl sulfide (CEES), induces tissue damage similar to HD. Herein we studied the molecular …

[HTML][HTML] Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation

N Tewari-Singh, AK Jain, S Inturi, C Agarwal, CW White… - 2012 - journals.plos.org
Chemical warfare agent sulfur mustard (HD) inflicts delayed blistering and incapacitating
skin injuries. To identify effective countermeasures against HD-induced skin injuries, efficacy …

Mustard gas: imminent danger or eminent threat?

MJ Geraci - Annals of Pharmacotherapy, 2008 - journals.sagepub.com
Objective: To increase awareness of the widespread environmental prevalence of the
chemical warfare agent mustard gas, examine the acute and chronic toxic effects to exposed …

Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor

P McNutt, T Hamilton, M Nelson, A Adkins, A Swartz… - Cornea, 2012 - journals.lww.com
Purpose: Sulfur mustard (SM) exposure results in dose-dependent morbidities caused by
cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve …