Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance
MK Ediriweera, KH Tennekoon… - Seminars in cancer …, 2019 - Elsevier
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …
Oncogenic PI3K deregulates transcription and translation
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer
pathogenesis. Experimental data document a requirement for deregulation of both …
pathogenesis. Experimental data document a requirement for deregulation of both …
Class I PI3K in oncogenic cellular transformation
L Zhao, PK Vogt - Oncogene, 2008 - nature.com
Class I phosphoinositide 3-kinase (PI3K) is a dimeric enzyme, consisting of a catalytic and a
regulatory subunit. The catalytic subunit occurs in four isoforms designated as p110α …
regulatory subunit. The catalytic subunit occurs in four isoforms designated as p110α …
Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma
Ovarian clear cell carcinoma (CCC) is one of the most malignant types of ovarian
carcinomas, particularly at advanced stages. Unlike the more common type of ovarian …
carcinomas, particularly at advanced stages. Unlike the more common type of ovarian …
The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations
PIK3CA, one of the two most frequently mutated oncogenes in human tumors, codes for
p110α, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform α (PI3Kα …
p110α, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform α (PI3Kα …
Oncogenic mutations of PIK3CA in human cancers
The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
Oncogenic PI3K and its role in cancer
Y Samuels, K Ericson - Current opinion in oncology, 2006 - journals.lww.com
The PI3K signaling pathway is dysregulated by a variety of mechanisms in a large fraction of
human tumors. Both mutational and functional analyses have shown that PIK3CA is an …
human tumors. Both mutational and functional analyses have shown that PIK3CA is an …
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
L Zhao, PK Vogt - Proceedings of the National Academy of …, 2008 - National Acad Sciences
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is up-regulated in cancer.
PIK3CA, the gene coding for the catalytic subunit p110α of PI3K, is mutated in≈ 30% of …
PIK3CA, the gene coding for the catalytic subunit p110α of PI3K, is mutated in≈ 30% of …
Cancer-specific mutations in PIK3CA are oncogenic in vivo
AG Bader, S Kang, PK Vogt - Proceedings of the National …, 2006 - National Acad Sciences
The PIK3CA gene, coding for the catalytic subunit p110α of class IA phosphatidylinositol 3-
kinases (PI3Ks), is frequently mutated in human cancer. Mutated p110α proteins show a …
kinases (PI3Ks), is frequently mutated in human cancer. Mutated p110α proteins show a …
[HTML][HTML] Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer
JA McCubrey, D Rakus, A Gizak, LS Steelman… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …