Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

For decades, interactions between the enteric neuromuscular apparatus and the central
nervous system have served as the primary focus of pathophysiological research in the …

Anxiety disorders are the most prevalent mental health conditions. Although they are less
visible than schizophrenia, depression, and bipolar disorder, they can be just as disabling …

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is
still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is …

Penile erection is a perfect example of microcirculation modulated by psychological factors
and hormonal status. It is the result of a complex neurovascular process that involves the …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …

Abstract The neuromodulator serotonin (5-HT) has been implicated in a variety of functions
that involve patience or impulse control. Many of these effects are consistent with a long …

The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …