Abstract Human enterovirus 71 (HEV71) is the cause of hand, foot and mouth disease and
associated neurological complications in children under five years of age. There has been …

Reproduction is inherently risky, in part because genomic replication can introduce new
mutations that are usually deleterious toward fitness. This risk is especially severe for …

Reverse transcription is an important early step in retrovirus replication and is a key point
targeted by evolutionarily conserved host restriction factors (eg, APOBEC3G, SamHD1) …

Synthetic nucleoside mimics are re‐emerging as crucial contenders for antiviral and
anticancer medications. While, Ribavirin stands out for its unique antiviral properties …

Lethal mutagenesis is a transition towards virus extinction mediated by enhanced mutation
rates during viral genome replication. Theoretical studies suggest that viruses can evolve …

RNA virus replication takes place at a very high error rate, and additional increases in this
parameter can produce the extinction of virus infectivity. Nevertheless, RNA viruses can …

A series of N6-aminopurine-9-β-d-ribonucleosides and ribose-modified 3′-C-methyl
analogues substituted at N6-position with a small group like hydroxy, methoxy or amino …

Several methods for the preparation of some N6-substituted adenosines based on selective
1-N-alkylation with subsequent Dimroth rearrangement were developed. The proposed …

Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its
mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the …

Background Small molecule inhibitors of RNA virus replication are potent antiviral drugs and
useful to dissect selected steps in the replication process. To identify antiviral compounds …