Cells are inherently dynamic, whether they are responding to environmental conditions or
simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their …

Bacteria are highly adaptive microorganisms that thrive in a wide range of growth conditions
via changes in cell morphologies and macromolecular composition. How bacterial …

Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …

How cells regulate their cell cycles is a central question for cell biology. Models of cell size
homeostasis have been proposed for bacteria, archaea, yeast, plant, and mammalian cells …

Balanced biosynthesis is the hallmark of bacterial cell physiology, where the concentrations
of stable proteins remain steady. However, this poses a conceptual challenge to modeling …

The bacterium Escherichia coli initiates replication once per cell cycle at a precise volume
per origin and adds an on average constant volume between successive initiation events …

Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy
known as the adder. This concept applies to various microbes and is often explained as the …

Despite much progress, image processing remains a significant bottleneck for high-
throughput analysis of microscopy data. One popular platform for single-cell time-lapse …

Classic models of cell size control consider that cells divide when reaching a threshold, eg,
size, age, or size extension. The molecular basis of the threshold involves multiple layers of …

Replication initiation, especially the widely conserved master initiator protein DnaA, is one of
the most well-studied biological problems in bacteria. Specifically, conversion between the …