Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

The discovery of stem cells that can generate neural tissue has raised new possibilities for
repairing the nervous system. A rush of papers proclaiming adult stem cell plasticity has …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

Entity or Function? specific adult stem cell may need to be expanded. Accordingly, adult
stem cells may not only act locally in the tissues in which they reside, but may also be …

Specialized cellular microenvironments, or 'niches', modulate stem cell properties, including
cell number, self-renewal and fate decisions,. In the adult brain, niches that maintain a …

The spatio-temporal timing of the last round of mitosis, followed by the migration of
neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is …

The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are
critical for development of the nervous system. The effects of BMP signaling on neural stem …

Glioblastoma remains the most common and devastating primary brain tumor despite
maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) …

DNA methylation is a major epigenetic factor that has been postulated to regulate cell
lineage differentiation. We report here that conditional gene deletion of the maintenance …

The generation of a functional nervous system involves a multitude of steps that are
controlled by just a few families of extracellular signaling molecules. Among these, the …