Early-stage symptomatic osteoarthritis of the knee—time for action
A Mahmoudian, LS Lohmander, A Mobasheri… - Nature Reviews …, 2021 - nature.com
Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …
Inhibition of MMPs and ADAM/ADAMTS
CJ Malemud - Biochemical pharmacology, 2019 - Elsevier
Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …
Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression
Background Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the
leading cause of disability worldwide. The progressive loss of hyaline cartilage extracellular …
leading cause of disability worldwide. The progressive loss of hyaline cartilage extracellular …
MRI-based texture analysis of infrapatellar fat pad to predict knee osteoarthritis incidence
Background Infrapatellar fat pad (IPFP) quality has been implicated as a marker for
predicting knee osteoarthritis (KOA); however, no valid quantification for subtle IPFP …
predicting knee osteoarthritis (KOA); however, no valid quantification for subtle IPFP …
Pharmacotherapy for knee osteoarthritis: current and emerging therapies
Introduction Osteoarthritis (OA) is the leading cause of pain, loss of function and disability in
the elderly, with the knee being the most impactful joint affected. Currently, there is still no …
the elderly, with the knee being the most impactful joint affected. Currently, there is still no …
Injectable temperature-sensitive hydrogel loaded with IL-36Ra for the relief of osteoarthritis
Y Yi, G Chen, S Gong, L Han, T Gong… - ACS Biomaterials …, 2023 - ACS Publications
Osteoarthritis (OA) is an inflammatory disease accompanied by synovial joint inflammation,
and IL-36 plays an important role in this process. Local application of IL-36 receptor …
and IL-36 plays an important role in this process. Local application of IL-36 receptor …
Systemic drugs with impact on osteoarthritis
Articular cartilage has a complex structure and metabolism which allow for a proper
movement within joints. Nevertheless, several systemically administered pharmacological …
movement within joints. Nevertheless, several systemically administered pharmacological …
Sprifermin: a recombinant human fibroblast growth factor 18 for the treatment of knee osteoarthritis
Introduction Osteoarthritis (OA) is a serious and incurable disease leading the disability.
Surgical treatment is the last but not necessarily the best approach for patients with high …
Surgical treatment is the last but not necessarily the best approach for patients with high …
[PDF][PDF] Disease modification in osteoarthritis: are we there yet
ABSTRACT A disease-modifying osteoarthritis drug (DMOAD) is a drug that modifies the
underlying OA pathophysiology and potentially inhibits the structural damage to prevent or …
underlying OA pathophysiology and potentially inhibits the structural damage to prevent or …
p-Coumaric acid attenuates IL-1β-induced inflammatory responses and cellular senescence in rat chondrocytes
X Huang, Y You, Y Xi, B Ni, X Chu, R Zhang, H You - Inflammation, 2020 - Springer
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by
cartilage degradation. p-Coumaric acid (PCA), a dietary phenolic compound, has exerted …
cartilage degradation. p-Coumaric acid (PCA), a dietary phenolic compound, has exerted …