Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central
nervous system (CNS) due to an increase of abnormal peripherally auto-reactive T …

Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

To assess the potential role of autophagy in amyotrophic lateral sclerosis (ALS), lumbar
spinal cords in a total of 19 sporadic ALS cases and 27 age-matched controls were …

Amyotrophic lateral sclerosis is a devastating, progressive neurodegenerative disease that
affects upper and lower motor neurons. Although several genes are identified as the cause …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Autophagy is implicated in the pathogenesis of major neurodegenerative disorders although
concepts about how it influences these diseases are still evolving. Once proposed to be …

Autophagy is a highly conserved intracellular pathway involved in the elimination of proteins
and organelles by lysosomes. Known originally as an adaptive response to nutrient …

Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but
extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic …

We studied five individuals from three Jewish Bukharian families affected by an apparently
autosomal-recessive form of hereditary spastic paraparesis accompanied by severe …

Increasing evidence indicates lithium (Li+) efficacy in neuropsychiatry, pointing to
overlapping mechanisms that occur within distinct neuronal populations. In fact, the same …