Objective: Studies examining the link between objective measures of total daily physical
activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an …

Diabetes mellitus is associated with an increase in the risk of dementia and the proportion of
patients who convert from mild cognitive impairment (MCI) to dementia. In addition to MCI …

Background Mild cognitive impairment (MCI) is an intermediate phase between normal
cognitive ageing and overt dementia, with amnesic MCI (aMCI) being the dominant subtype …

BACKGROUND AND AIMS: Global population aging has been one of the defining
processes of the twentieth century, with profound economic, political and social …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

Aims/Hypothesis Accumulating evidence suggests an association between coronary heart
disease and risk for cognitive impairment or dementia, but no study has systematically …

Background: Although poor social relationships are assumed to contribute to cognitive
decline, meta-analytic approaches have not been applied. Individual study results are mixed …

Objective: Our aim was to test the association of vascular risk factor exposure in midlife with
progression of MRI markers of brain aging and measures of cognitive decline. Methods: A …

With the aspiration for a long life now achievable for many individuals, the status of old age
as a distinct social position has become problematic. In this radical re-examination of the …

We examined the association of social activity with cognitive decline in 1138 persons
without dementia at baseline with a mean age of 79.6 (SD= 7.5) who were followed for up to …