SARS‐CoV‐2 and its variants of concern including Omicron: a never ending pandemic

RK Mohapatra, S Kuppili… - Chemical Biology & …, 2022 - Wiley Online Library
The ongoing COVID‐19 pandemic caused by SARS‐CoV‐2 is associated with high
morbidity and mortality. This zoonotic virus has emerged in Wuhan of China in December …

SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters

F Armando, G Beythien, FK Kaiser, L Allnoch… - Nature …, 2022 - nature.com
Since its discovery in 2019, multiple variants of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) have been identified. This study investigates virus spread and …

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

T Kehrer, A Cupic, C Ye, S Yildiz, M Bouhaddou… - Cell Host & Microbe, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …

COVID-19 and multiple sclerosis: a complex relationship possibly aggravated by low vitamin D levels

WD Fernandes de Souza, DM Fonseca, A Sartori - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an exceptionally
transmissible and pathogenic coronavirus that appeared at the end of 2019 and triggered a …

SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

CM Lieber, RM Cox, J Sourimant, JD Wolf… - Nature …, 2022 - nature.com
SARS-CoV-2 variants of concern (VOC) have triggered infection waves. Oral antivirals such
as molnupiravir promise to improve disease management, but efficacy against VOC delta …

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

WJ Tu, M Melino, J Dunn, RD McCuaig… - Nature …, 2023 - nature.com
In vitro, ACE2 translocates to the nucleus to induce SARS-CoV-2 replication. Here, using
digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters …

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

E Wyler, JM Adler, K Eschke, GT Alves, S Peidli, F Pott… - Molecular Therapy, 2022 - cell.com
For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting …

Vitamin D and the Ability to Produce 1,25(OH)2D Are Critical for Protection from Viral Infection of the Lungs

J Arora, DR Patel, MKJ Nicol, CJ Field, KH Restori… - Nutrients, 2022 - mdpi.com
Vitamin D supplementation is linked to improved outcomes from respiratory virus infection,
and the COVID-19 pandemic renewed interest in understanding the potential role of vitamin …

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

GR Meehan, V Herder, J Allan, X Huang, K Kerr… - PLoS …, 2023 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve
throughout the coronavirus disease-19 (COVID-19) pandemic, giving rise to multiple …

Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants

CB Stauft, P Selvaraj, F D'Agnillo, CA Meseda… - Nature …, 2023 - nature.com
Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal
protection by vaccines against a respiratory virus, such as the severe acute respiratory …