Idiopathic pulmonary fibrosis: Current and future treatment
DS Glass, D Grossfeld, HA Renna… - The clinical …, 2022 - Wiley Online Library
Objectives Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease characterized
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …
by dry cough, fatigue, and progressive exertional dyspnea. Lung parenchyma and …
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on …
Background Idiopathic pulmonary fibrosis (IPF) is an age-related, chronic, irreversible
fibrotic lung disease. IPF is associated with increased senescent cells burden, which may be …
fibrotic lung disease. IPF is associated with increased senescent cells burden, which may be …
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur… - …, 2019 - thelancet.com
Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
Shared and distinct mechanisms of fibrosis
JHW Distler, AH Györfi, M Ramanujam… - Nature Reviews …, 2019 - nature.com
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
Regeneration or repair? The role of alveolar epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF)
P Confalonieri, MC Volpe, J Jacob, S Maiocchi… - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial …
with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial …
Idiopathic pulmonary fibrosis
FJ Martinez, HR Collard, A Pardo, G Raghu… - Nature reviews Disease …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
Cellular senescence mediates fibrotic pulmonary disease
MJ Schafer, TA White, K Iijima, AJ Haak… - Nature …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …
leading to compromised lung function. Cellular senescence markers are detectable within …
TGF-β signaling in lung health and disease
A Saito, M Horie, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Transforming growth factor (TGF)-β is an evolutionarily conserved pleiotropic factor that
regulates a myriad of biological processes including development, tissue regeneration …
regulates a myriad of biological processes including development, tissue regeneration …