Expression and function of NF-Y subunits in cancer

D Dolfini, N Gnesutta, R Mantovani - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
NF-Y is a Transcription Factor-TF-targeting the CCAAT box regulatory element. It consists of
the NF-YB/NF-YC heterodimer, each containing an Histone Fold Domain-HFD-and the …

Genome-wide screening and identification of nuclear Factor-Y family genes and exploration their function on regulating abiotic and biotic stress in potato (Solanum …

G Xuanyuan, Q Lian, R Jia, M Du, L Kang, Y Pu… - Gene, 2022 - Elsevier
Abstract The Nuclear Factor-Y (NF-Y) transcription factor (TF), which includes three distinct
subunits (NF-YA, NF-YB and NF-YC), is known to manipulate various aspects of plant …

Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development

X Vendrell, P de Castro, L Escrich, N Grau… - Human …, 2024 - academic.oup.com
STUDY QUESTION How do transcriptomics vary in haploid human androgenote embryos at
single cell level in the first four cell cycles of embryo development? SUMMARY ANSWER …

[HTML][HTML] Phylogeny of NF-YA trans-activation splicing isoforms in vertebrate evolution

A Bernardini, A Gallo, N Gnesutta, D Dolfini… - Genomics, 2022 - Elsevier
NF-Y is a trimeric pioneer Transcription Factor (TF) whose target sequence–the CCAAT box–
is present in~ 25% of mammalian promoters. We reconstruct the phylogenetic history of the …

[HTML][HTML] Genomic binding of NF-Y in mouse and human cells

M Ronzio, A Bernardini, V Taglietti, M Ceribelli… - Genomics, 2024 - Elsevier
NF-Y is a Transcription Factor that regulates transcription through binding to the CCAAT-
box. To understand its strategy, we analyzed 16 ChIP-seq datasets from human and mouse …

NF-YA isoforms with alternative splicing of exon-5 in Aves

A Gallo, D Dolfini, A Bernardini, N Gnesutta… - Genomics, 2023 - Elsevier
NF-YA, the regulatory subunit of the trimeric CCAAT-binding transcription factor NF-Y, is
present in vertebrates in two major alternative spliced isoforms: NF-YAl and NF-YAs …

The USR domain of USF1 mediates NF-Y interactions and cooperative DNA binding

A Bernardini, M Lorenzo, A Chaves-Sanjuan… - International Journal of …, 2021 - Elsevier
The trimeric CCAAT-binding NF-Y is a “pioneer” Transcription Factor-TF-known to cooperate
with neighboring TFs to regulate gene expression. Genome-wide analyses detected a …

Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk Mutations

MES Capps, AJ Moyer, CL Conklin, V Martina… - bioRxiv, 2024 - biorxiv.org
Hundreds of human mutations are linked to autism and related disorders, yet the functions of
many of these mutated genes during vertebrate neurodevelopment are unclear. We …

IL PUNTO DI VISTA DI UN REGOLATORE EPIGENETICO DELL'ESPRESSIONE GENICA, COMUNE A UOMO E PIANTE

R Mantovani - Istituto Lombardo-Accademia di Scienze e Lettere …, 2020 - ilasl.org
The regulation of gene expression is at the heart of all the fundamental processes of living
organisms. It is controlled by Transcriptional Factors which, by binding to specific DNA …