ROS generation and antioxidant defense systems in normal and malignant cells

AV Snezhkina, AV Kudryavtseva… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Animal models and therapeutic molecular targets of cancer: utility and limitations

M Cekanova, K Rathore - Drug design, development and therapy, 2014 - Taylor & Francis
Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Chronic inflammation and oxidative stress in human carcinogenesis

A Federico, F Morgillo, C Tuccillo… - … journal of cancer, 2007 - Wiley Online Library
A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic
transformation. In general, the longer the inflammation persists, the higher the risk of cancer …

[HTML][HTML] MMP-9 supplied by bone marrow–derived cells contributes to skin carcinogenesis

LM Coussens, CL Tinkle, D Hanahan, Z Werb - Cell, 2000 - cell.com
The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias
and invasive cancers of the epidermis in a mouse model of multi-stage tumorigenesis …

Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

D Bagga, L Wang, R Farias-Eisner… - Proceedings of the …, 2003 - National Acad Sciences
Omega-6 (ω-6) polyunsaturated fatty acids (PUFA), abundant in the Western diet, are
precursors for a number of key mediators of inflammation including the 2-series of …

Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies

H Tapiero, GN Ba, P Couvreur, KD Tew - Biomedicine & pharmacotherapy, 2002 - Elsevier
Linoleic and alpha-linolenic acids, obtained from plant material in the diet are the precursors
in tissues of two families with opposing effects which are referred to as “essential fatty …

Ewing's sarcoma family of tumors: current management

M Bernstein, H Kovar, M Paulussen, RL Randall… - The …, 2006 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …

Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels

ME Olsson, KE Gustavsson, S Andersson… - Journal of agricultural …, 2004 - ACS Publications
The effects of 10 different extracts of fruits and berries on cell proliferation of colon cancer
cells HT29 and breast cancer cells MCF-7 were investigated. The fruits and berries used …

Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis

DA Corley, K Kerlikowske, R Verma, P Buffler - Gastroenterology, 2003 - Elsevier
Background & Aims: Esophageal carcinomas have high fatality rates, making
chemoprevention agents desirable. We performed a systematic review with meta-analysis of …

Cyclooxygenase-2 (COX-2)–independent anticarcinogenic effects of selective COX-2 inhibitors

S Grösch, TJ Maier, S Schiffmann… - Journal of the National …, 2006 - academic.oup.com
Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …