Closed-loop vagus nerve stimulation for the treatment of cardiovascular diseases: state of the art and future directions

MM Ottaviani, F Vallone, S Micera… - Frontiers in …, 2022 - frontiersin.org
The autonomic nervous system exerts a fine beat-to-beat regulation of cardiovascular
functions and is consequently involved in the onset and progression of many cardiovascular …

The vagus nerve in cardiovascular physiology and pathophysiology: from evolutionary insights to clinical medicine

PS Rajendran, J Hadaya, SS Khalsa, C Yu… - Seminars in Cell & …, 2024 - Elsevier
The parasympathetic nervous system via the vagus nerve exerts profound influence over the
heart. Together with the sympathetic nervous system, the parasympathetic nervous system is …

Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction

KJ Schunke, J Rodriguez, J Dyavanapalli… - Basic research in …, 2023 - Springer
Altered autonomic balance is a hallmark of numerous cardiovascular diseases, including
myocardial infarction (MI). Although device-based vagal stimulation is cardioprotective …

The plasticity of cardiac sympathetic nerves and its clinical implication in cardiovascular disease

H Kanazawa, K Fukuda - Frontiers in Synaptic Neuroscience, 2022 - frontiersin.org
The heart is electrically and mechanically controlled by the autonomic nervous system,
which consists of both the sympathetic and parasympathetic systems. It has been …

Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure

TW Dasari, P Chakraborty, P Mukli, K Akhtar… - Clinical Autonomic …, 2023 - Springer
Purpose Acute decompensated heart failure (ADHF) is associated with inflammation,
oxidative stress, and excess sympathetic drive. It is unknown whether neuromodulation …

Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats

V Agarwal, AS Kaushik, R Chaudhary… - Naunyn-Schmiedeberg's …, 2024 - Springer
Chronically stressed patients often have low vagal tone and increased levels of
proinflammatory cytokines, which increase their risk for developing cardiac dysfunction …

Quantification of large transmural biopsies reveals heterogeneity in innervation patterns in chronic myocardial infarction

HS Chen, LM Voortman, JC van Munsteren… - Clinical …, 2023 - jacc.org
Background Abnormal cardiac innervation plays an important role in arrhythmogenicity after
myocardial infarction (MI). Data regarding reperfusion models and innervation abnormalities …

Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis

HS Chen, L van Roon, J Schoones… - Annals of …, 2023 - Taylor & Francis
Background Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is
associated with arrhythmogenesis and sudden cardiac death. The characteristics of cardiac …

Threshold adjusted vagus nerve stimulation after asphyxial cardiac arrest results in neuroprotection and improved survival

RC Choudhary, U Ahmed, M Shoaib, E Alper… - Bioelectronic …, 2022 - Springer
Background Vagus nerve stimulation (VNS) has shown therapeutic potential in a variety of
different diseases with many ongoing clinical trials. The role of VNS in reducing ischemic …

[HTML][HTML] Ultrasound-driven piezoelectret-based nanogenerator stimulates vagus nerve for myocardial infarction treatment

L Wang, X Li, Q Jin, R Wang, W Wang, X Cheng, C Tan… - Nano Energy, 2024 - Elsevier
Myocardial infarction (MI) stands as the predominant cause of morbidity and mortality within
the spectrum of cardiovascular diseases, with an unfavorable long-term prognosis. Vagus …