Aberrant DNA methylation status of endometriosis: epigenetics as the pathogenesis, biomarker and therapeutic target

K Nasu, Y Kawano, Y Tsukamoto… - Journal of Obstetrics …, 2011 - Wiley Online Library
Endometriosis, a common, benign, estrogen‐dependent disease affecting 3–10% of women
of reproductive age, is characterized by the ectopic growth of endometrial tissue that is found …

Role of oxidative stress in epigenetic modification in endometriosis

F Ito, Y Yamada, A Shigemitsu… - Reproductive …, 2017 - journals.sagepub.com
Aberrant DNA methylation and histone modification are associated with an increased risk of
reproductive disorders such as endometriosis. However, a cause–effect relationship …

Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis

L Aghajanova, K Tatsumi, JA Horcajadas… - Biology of …, 2011 - academic.oup.com
Eutopic endometrium in endometriosis has molecular evidence of resistance to
progesterone (P4) and activation of the PKA pathway in the stromal compartment. To …

Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action

DB Martinez-Arguelles, V Papadopoulos - Steroids, 2010 - Elsevier
Steroid hormones participate in organ development, reproduction, body homeostasis, and
stress responses. The steroid machinery is expressed in a development-and tissue-specific …

Altered genome-wide methylation in endometriosis

H Naqvi, Y Ilagan, G Krikun… - Reproductive …, 2014 - journals.sagepub.com
Endometriosis has been associated with aberrant methylation in the eutopic endometrium.
Using a genome-wide methylation array, we identified differentially methylated genes in the …

Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice

Y Lu, J Nie, X Liu, Y Zheng, SW Guo - Human reproduction, 2010 - academic.oup.com
BACKGROUND The aim of this study was to evaluate the effect of trichostatin A (TSA) in a
mouse model of endometriosis on serum tumour necrosis factor α (TNFα) levels, hotplate …

Epigenetic regulation of the pathological process in endometriosis

KY Hsiao, MH Wu, SJ Tsai - Reproductive Medicine and …, 2017 - Wiley Online Library
Background Endometriosis is one of the most common gynecological diseases that greatly
compromises the quality of life in affected individuals. A growing body of evidence shows …

[HTML][HTML] Machine learning classifiers for endometriosis using transcriptomics and methylomics data

S Akter, D Xu, SC Nagel, JJ Bromfield, K Pelch… - Frontiers in …, 2019 - frontiersin.org
Endometriosis is a complex and common gynecological disorder yet a poorly understood
disease affecting about 176 million women worldwide and causing significant impact on …

[HTML][HTML] Hypoxia and reproductive health: The role of hypoxia in the development and progression of endometriosis

WN Li, MH Wu, SJ Tsai - Reproduction, 2021 - rep.bioscientifica.com
Endometriosis is a benign gynecological disease that affects about 10% women of
reproductive age. Patients with endometriosis suffer from long-term coexistence with …

[HTML][HTML] Epigenetic alterations affecting transcription factors and signaling pathways in stromal cells of endometriosis

I Yotova, E Hsu, C Do, A Gaba, M Sczabolcs, S Dekan… - PLoS …, 2017 - journals.plos.org
Endometriosis is characterized by growth of endometrial-like tissue outside the uterine
cavity. Since its pathogenesis may involve epigenetic changes, we used Illumina 450K …