Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …
[HTML][HTML] Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis
X Liu, M Li, Z Chen, Y Yu, H Shi, Y Yu, Y Wang… - Basic Research in …, 2022 - Springer
Abstract Treatment options for myocarditis are currently limited. Inhibition of calpains has
been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the …
been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the …
P2X7 receptor and the NLRP3 inflammasome: Partners in crime
P Pelegrin - Biochemical pharmacology, 2021 - Elsevier
Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …
energetics and which on the other is a ubiquitous signaling molecule when released into the …
[HTML][HTML] Inflammasome formation in the lungs of patients with fatal COVID-19
S Toldo, R Bussani, V Nuzzi, A Bonaventura… - Inflammation …, 2021 - Springer
Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2,
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …
[HTML][HTML] COVID-19 infection: an overview on cytokine storm and related interventions
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …
Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …
The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms
C Baldini, FR Moriconi, S Galimberti… - European Heart …, 2021 - academic.oup.com
Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …
[HTML][HTML] Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction
Acute myocardial infarction (AMI) induces blood leukocytosis, which correlates inversely
with patient survival. The molecular mechanisms leading to leukocytosis in the infarcted …
with patient survival. The molecular mechanisms leading to leukocytosis in the infarcted …
[HTML][HTML] Targeting inflammatory pathways in cardiovascular disease: the inflammasome, interleukin-1, interleukin-6 and beyond
P Libby - Cells, 2021 - mdpi.com
Recent clinical trials have now firmly established that inflammation participates causally in
human atherosclerosis. These observations point the way toward novel treatments that add …
human atherosclerosis. These observations point the way toward novel treatments that add …
Inflammation in acute myocardial infarction: the good, the bad and the ugly
Convergent experimental and clinical evidence have established the pathophysiological
importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in …
importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in …