Mechanisms and sequelae of E‐cadherin silencing in hereditary diffuse gastric cancer
Abstract Around 25–40% of cases of hereditary diffuse gastric cancer (HDGC) are caused by
heterozygous E‐cadherin (CDH1) germline mutations. The mechanisms for loss of the …
heterozygous E‐cadherin (CDH1) germline mutations. The mechanisms for loss of the …
CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study
PR Benusiglio, D Malka, E Rouleau… - Journal of medical …, 2013 - jmg.bmj.com
Introduction CDH1 predisposes primarily to diffuse gastric cancer (DGC). Multiple DGC
cases in a family, DGC at a young age in an individual or the combination of DGC …
cases in a family, DGC at a young age in an individual or the combination of DGC …
Gastric cancer in the elderly: an overview
MW Saif, N Makrilia, A Zalonis, M Merikas… - European Journal of …, 2010 - Elsevier
AIMS: Gastric cancer in the elderly represents a distinct entity with specific
clinicopathological characteristics and the majority of affected patients belong to this age …
clinicopathological characteristics and the majority of affected patients belong to this age …
Familial and hereditary gastric cancer, an overview
F Carneiro - Best Practice & Research Clinical Gastroenterology, 2022 - Elsevier
There are three major hereditable syndromes that affect primarily the stomach: hereditary
diffuse gastric cancer (HDGC), gastric adenocarcinoma and proximal polyposis of the …
diffuse gastric cancer (HDGC), gastric adenocarcinoma and proximal polyposis of the …
Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients
PC Hebbard, A Macmillan, D Huntsman… - Annals of surgical …, 2009 - Springer
Background Hereditary diffuse gastric cancer (HDGC) results from truncating mutations of
the CDH1 (E-cadherin) gene. It is an autosomal dominant cancer susceptibility syndrome …
the CDH1 (E-cadherin) gene. It is an autosomal dominant cancer susceptibility syndrome …
Hereditary diffuse gastric cancer: diagnosis and management
V Blair, I Martin, D Shaw, I Winship, D Kerr… - Clinical …, 2006 - Elsevier
Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome defined by germline
mutation of the E-cadherin gene (CDH-1). The cumulative risk for advanced gastric cancer in …
mutation of the E-cadherin gene (CDH-1). The cumulative risk for advanced gastric cancer in …
Molecular basis of gastric cancer development and progression
L Zheng, L Wang, J Ajani, K Xie - Gastric cancer, 2004 - Springer
Gastric cancer is one of the leading causes of cancer death worldwide. Because of its
heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis …
heterogeneity, gastric cancer has been an interesting model for studying carcinogenesis …
Chromoendoscopic surveillance in hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy?
D Shaw, V Blair, A Framp, P Harawira, M McLeod… - Gut, 2005 - gut.bmj.com
Background: Hereditary diffuse gastric cancer (HDGC) is defined by germline mutations in
the E-cadherin gene, CDH-1. The first family in which CDH-1 mutations were identified was …
the E-cadherin gene, CDH-1. The first family in which CDH-1 mutations were identified was …
A systematic review of the indications for genetic testing and prophylactic gastrectomy among patients with hereditary diffuse gastric cancer
R Seevaratnam, N Coburn, R Cardoso, M Dixon… - Gastric cancer, 2012 - Springer
Background Hereditary diffuse gastric cancer (HDGC) is a familial cancer syndrome
specifically associated with germline mutations to the E-cadherin (CDH1) gene. HDGC is …
specifically associated with germline mutations to the E-cadherin (CDH1) gene. HDGC is …
Genetics, pathology, and clinics of familial gastric cancer
Gastric cancer is relatively common worldwide, mainly in its sporadic form, but familial
aggregation of the disease may be seen in approximately 10% of the cases. This suggests a …
aggregation of the disease may be seen in approximately 10% of the cases. This suggests a …